Bioactive self-assembled peptide nanofibers for corneal stroma regeneration
نویسندگان
چکیده
منابع مشابه
tissue regeneration through self-assembled peptide amphiphile nanofibers
introduction: in the present study, we hypothesized that a novel approach to promote vascularization would be to create injectable three dimensional (3-d) scaffolds within growth factor that enhance the sustained release of growth factor and induce the angiogenesis. material and methods: we demonstrate that a 3-d scaffold can be formed by mixing of peptide-amphiphile (pa) aqueous solution with ...
متن کاملTissue Regeneration through Self-Assembled Peptide Amphiphile Nanofibers
1. International Center for Young Scientists, National Institute for Materials Science, Nano and Biomaterials Research Building, Tsukuba, Ibaraki, JAPAN 2. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University Hospital, Kyoto, JAPAN 3. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA 4. Medicin...
متن کاملSelf-Assembling Multidomain Peptide Nanofibers for Delivery of Bioactive Molecules and Tissue Regeneration
Multidomain peptides (MDPs) are a class of self-assembling peptides that are organized in a β-sheet motif, resulting in a nanofibrous architecture. This structure is stabilized by hydrophobic packing in the fiber core and a hydrogen-bonding network down the fiber long axis. Under easily controllable conditions, regulated by electrostatic interactions between the peptides and the pH and salt com...
متن کاملBioinspired self-assembled peptide nanofibers with thermostable multivalent α-helices.
The stabilization of peptide's active conformation is a critical determinant of its target binding efficiency. Here we present a structure-based self-assembly strategy for the design of nanostructures with multiple and thermostable α-helices using bioinspired peptide amphiphiles. The design principle was inspired by the oligomerization of the human immunodeficiency virus type-1 (HIV-1) Rev prot...
متن کاملThe internal structure of self-assembled peptide amphiphiles nanofibers{
The self-assembly of peptide amphiphiles (PAs) into nanofibers and their bioactivity as well as physical properties have been investigated by our laboratory over the past few years. We report here on the use of transmission infrared spectroscopy (IR) and polarization modulation-infrared reflection-absorption spectroscopy (PM-IRRAS) to characterize the internal structure of the nanofibers. Depos...
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ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2014
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2013.12.002